Explore Structural Aspects
Protein Data Bank(PDB) is the database for experimentally determined proteins solved
with X-ray crystallography or NMR studies.
DHFR structure has been determined with bound NADPH cofactor and a lipophilic
Open PDB Homepage http://www.rcsb.org/pdb/
In search box write 1KMV that is the PDB ID for this
protein, PDB ID is typically four lettered, if you don't have the ID for any protein then you can check Full Text Search option.
Structure Explorer for 1KMV opens. There
is lot of information on this page.
You can see or download the structure if you have one of the molecular visualization
tools. Most of the topics are very easy to understand. Here is a little insight into
PDB structure explorer:-
The initial summary information page gives the details about the title and the source
of the protein.
View Structure-You can visualize the structure through various tools.If you have the Java installed onto your computer click on the QuickPDB option.It gives you red colored alpha carbon chain .Explore the structure instantly by
rotating, translating or zooming it.
You can learn about the structural neighbors through the next option
Spot the Ramachandran Plot and various options in the Geometry section.
You can the also know amino acid sequence in the Sequence Details options