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What is Bioinformatics ?

Bioinformatics is a science which uses computational techniques to analyze the
biological problems ; the science of developing and utilizing computer databases
and algorithms to accelerate and enhance biological research.

Bioinformatics is much more than what this definition says, its commonly referred
as dry lab work which accelerates the wet lab work drastically.

How bioinformatics emerged ?

Bioinformatics recently became the BUZZ word, after the human genome was
deciphered in Feb 2001.

But it all started way back in 1960's when the first bioinformatics database was
created by Dayhoff.

So here is a list of major events in bioinformatics over the last several decades.

 

1965

Margaret Dayhoff's Atlas of Protein Sequences

1970

Needleman-Wunsch algorithm

1971

Protein Data Bank was established with just 7 structures !!

1977

DNA sequencing and software to analyze it (Staden)

1980

EMBL Nucleotide Sequence Database was established

1981

Smith-Waterman algorithm developed

1981

The concept of a sequence motif (Doolittle)

1982

GenBank Release 3 made public

1982

Phage lambda genome sequenced

1983

Sequence database searching algorithm (Wilbur-Lipman)

1985

FASTP/FASTN: fast sequence similarity searching

1988

National Center for Biotechnology Information (NCBI) created at NIH/NLM

1988

EMBnet network for database distribution

1990

BLAST: fast sequence similarity searching

1991

EST: expressed sequence tag sequencing

1993

Sanger Centre, Hinxton, UK

1994

EMBL European Bioinformatics Institute, Hinxton, UK

1995

First bacterial genomes completely sequenced

1996

Yeast genome completely sequenced

1997

PSI-BLAST

1998

Worm (multicellular) genome completely sequenced

1999

Fly genome completely sequenced

2000

The genome for Pseudomonas aeruginosa (6.3 Mbp) is published.

2000

The A. thaliana genome (100 Mb) is sequenced.

2001

The human genome (3 Giga base pairs) is published.

Last updated: 30 October 2006

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